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Abstract #1607

Comparison of oxygenation MRI methods with cerebrovascular reactivity in Moyamoya disease using simultaneous [15O]-water PET/MRI

Audrey P Fan1, David Y.T. Chen2, David D. Shin3, Moss Y. Zhao1, Mohammad M. Khalighi1, Jun-Hyung Park1, Bin Shen1, Dawn Holley1, Kim Halbert1, Gary K. Steinberg4, and Greg Zaharchuk1
1Radiology, Stanford University, Stanford, CA, United States, 2Radiology, Taipei Medical University, Taipei, Taiwan, 3GE Healthcare, Menlo Park, CA, United States, 4Neurosurgery, Stanford University, Stanford, CA, United States

In this [15O]-water PET/MRI study, we compared two non-invasive MRI techniques to measure brain oxygen extraction fraction (OEF) in 10 patients with Moyamoya disease, a steno-occlusive disease of arteries at the base of the brain. Relative OEF from magnetic susceptibility in veins and tissue R2' inversely correlated with [15O]-water PET baseline cerebral blood flow and cerebrovascular reactivity (after vasodilation with acetazolamide). Susceptibility-based OEF in veins was abnormally elevated by 20.4% in regions with severe stenosis compared to healthy tissue. R2' maps showed a smaller OEF elevation (9.6%) that may be confounded by other physiological changes (e.g. blood volume) in disease.

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