Abstract #1852

Hippocampal concentration of glutamate: A comparative study of CEST and 1HMRS measurements at 7T.

Tomohisa Okada¹, Ravi Prakash Reddy Nanga², Koji Fujimoto¹, Dinh Ha Duy Thuy¹, Ravinder Reddy², Hideto Kuribayashi³, Yuta Urushibata³, Ravi Teja Seethamraju⁴, Sinyeob Ahn⁵, and Tadashi Isa¹

¹Kyoto University, Kyoto, Japan, ²University of Pennsylvania, Philadelphia, PA, United States, ³Siemens Healthcare K.K., Tokyo, Japan, ⁴Siemens Healthineers USA, Burlington, MA, United States, ⁵Siemens Healthineers USA, Berkeley, CA, United States

Chemical exchange saturation transfer of the glutamate (GluCEST) contrast is considered from glutamate to be about 70 - 75 %. Its values at the bilateral hippocampus were compared to those of ¹HMRS in 10 healthy subjects. Correlation between GluCEST contrast and glutamate from ¹HMRS measurements of all subjects was marginally significant (r = 0.44, p = 0.054), but it was statistically significant (r = 0.56, p = 0.030) when analysis was limited to ¹HMRS measurements with SNR ≥ 10. The GluCEST map gives regional difference in glutamate concentration in high resolution and is expected to facilitate investigation of the hippocampus.

This abstract and the presentation materials are available to members only; a login is required.

Join Here