Abstract #1853

Brain and immune system crosstalk: Examining the link between proinflammatory markers and glial markers measured with 1H-MRS at 7T

Carl-Johan Boraxbekk^1,2,3, Anna Lind¹, Esben Thade Petersen^1,4, Hartwig Roman Siebner^1,5,6, and Anouk Marsman¹

¹Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Hvidovre, Denmark, ²Department of Radiation Sciences, Umeå University, Umeå, Sweden, ³Institute of Sports Medicine Copenhagen (ISMC), Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark, ⁴Center for Magnetic Resonance, Department of Health Technology, Technical University of Denmark, Lyngby, Denmark, ⁵Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, ⁶Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark

Inflammation is proposed as one of the central pillars driving ageing. This study was the first to link peripheral inflammation to brain metabolite differences during normal ageing and to associate this to visuo-spatial working memory performance. Our data shows how peripheral inflammatory markers were associated with performance on visuo-spatial working memory and glial metabolic markers in ACC, Hippocampus, and Thalamus. The findings highlight the role of glial cells as part of the neurobiological link between peripheral inflammation and cognitive performance during ageing.

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