Optimal detection of many metabolites requires a specific TE, at which significant macromolecule signals are often present. The presence of macromolecule signals complicates the measurement of metabolite T1 because different spectral models may be necessary for macromolecules at different inversion recovery stage, therefore, potentially introducing additional errors. To minimize interference from macromolecules, we chose inversion times in such a way that the metabolite signals were changed by as much as 60% while the macromolecule signals were essentially unchanged. This avoided the T1 relaxation effect of macromolecules, and thus simplified data acquisition and post-processing.
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