Higher-numbered phased-array coils have been associated with significant increases in SNR. For this gain, one would expect more accurate and precise MRS measurements for a regular PRESS sequence processed with a fully automated program such as LCModel. However, the effects of increased SNR on a J-edited technique such as MEGA-PRESS for GABA measurements are not as straight-forward. In this study, we wish to compare the reproducibility of GABA+ and Glx measurements from an 8-channel and a 32-channel head coil in two cortical regions of interest: Anterior Cingulate Cortex (ACC) and Left-Dorsolateral Prefrontal Cortex (Lt-DLPFC).
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