Muscone is a compound that contributes to the smell of musk and attracts male mice. When mice are stimulated with muscone, their main olfactory bulb and olfactory cortex are activated, as revealed by immunohistochemistry. It is conceivable that the signals are further transduced in the cerebrum, resulting in the attraction behavior in male mice. It is important to identify the muscone-evoked activated regions in the whole brain and explore their biological significance. We previously developed a functional MRI method that uses repetitive odor stimulation and independent component analysis. We applied this method to identify the muscone-evoked activated regions.
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