Characterizing neuronal networks in animals is critical to further address their evolutions. Here we compared brain networks in humans and in mouse lemurs (Microcebus murinus), one of the more phylogenetically distant primates as compared to humans. Network hubs were split into parietal and frontal clusters in humans, while they were grouped in lemurs. Human’s default mode network (DMN) embedded more hubs than lemur's DMN. Mouse lemur's motor network embedded more hubs than human motor networks. Hubness properties could constitute a lever of evolution to adapt information flux to brain size and/or cerebral function.