Abstract #4123

Brain Volumetric Changes following MR Guided Focused Ultrasound Treatment for Parkinson’s Disease

Justin Schumacher¹, Li Jiang², Jiachen Zhuo², Howard Eisenberg³, Paul Fishman⁴, Dheeraj Gandhi², and Rao Gullapalli²

¹University of Maryland School of Medicine, Baltimore, MD, United States, ²Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, ³Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, United States, ⁴Neurology, University of Maryland School of Medicine, Baltimore, MD, United States

MR Guided Focused Ultrasound (MRgFUS) is a novel technique used to noninvasively lesion the brain for treatment of Parkinson’s Disease (PD). In this study 12 PD patients with asymmetric motor symptoms underwent MRgFUS pallidotomy and cortical thicknesses and subcortical volumes were measured pre and post treatment. Subcortical gray matter volume increases were observed 24 hours post treatment with bilateral decreases in basal ganglia gray matter volume 3-6 months post treatment. Cortical thicknesses decreases were observed in the frontal and temporal cortices of right-sided treated patients 3-6 months post treatment. These regions may play a role in the management of dyskinesias.

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