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Abstract #4124

MR guided blood-brain-barrier opening induced by focus ultrasound on Non-human primate

Hui Zhou1,2, Yang Liu3, Chao Zou1, Xiaojing Long3, Xin Liu1, and Hairong Zheng1
1Shenzhen Institutes of Advanced Technology´╝îChinese Academy of Sciences, Shenzhen, China, 2The Shenzhen College of Advanced Technology, University of Chinese Academy of Sciences, Shenzhen, China, 3Research center for medical AI, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

Magnetic Resonance Imaging(MRI) is highly recommended for estimation of the feasibility and safety of BBB opening. We opened BBB in three different deep brain areas of an non-human primate with a single element ultrasound transducer working at 300kHz without detectable edema, hemorrhage and abnormal behavior. We found that the BBB in gray matter was easier to be disrupted than that in white matter, suggesting that for a local BBB opening in deep brain on non-human primate and human subjects, array transduces with relative large assemble surface are required to avoid the BBB disruption in cerebral cortex.

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