Magnetic Resonance Imaging(MRI) is highly recommended for estimation of the feasibility and safety of BBB opening. We opened BBB in three different deep brain areas of an non-human primate with a single element ultrasound transducer working at 300kHz without detectable edema, hemorrhage and abnormal behavior. We found that the BBB in gray matter was easier to be disrupted than that in white matter, suggesting that for a local BBB opening in deep brain on non-human primate and human subjects, array transduces with relative large assemble surface are required to avoid the BBB disruption in cerebral cortex.
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