Abstract #4125

Effects of mild hyperthermia and pulsed high intensity focused ultrasound in a mouse models of Pancreatic Ductal Adenocarcinoma

Ravneet Vohra¹, Yak-Nam Wang², Helena Son³, Stephanie Totten³, Joo Ha Hwang⁴, and Donghoon Lee¹

¹Radiology, University of Washington, Seattle, WA, United States, ²Applied Physics Laboratory, University of Washington, Seattle, WA, United States, ³Division of Gastroenterology, University of Washington, Seattle, WA, United States, ⁴Medicine, Stanford University, Stanford, CA, United States

Pancreatic cancer is expected to become the second leading cause of the cancer related deaths in the USA by 2020. The ineffectiveness of conventional chemotherapeutics in Pancreatic Ductal Adenocarcinoma (PDA) is thought to be largely due to the extensive stromal desmoplasia which inadvertently increases the interstitial fluid pressure. High intensity focused ultrasound (HIFU) sonication was performed with temperature monitored by MRI. The aim of this study was to develop a target treatment of pulsed HIFU treatment combined with mild hyperthermia on PDA and to monitor the response to the therapy using multi-parametric MRI as a non-invasive biomarker.

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