Abstract #4338

DTI in early RRMS patients with correlation to clinical parameters and comparison to Healthy Controls

Abdulaziz Alshehri^1,2, Oun Al-iedani^1,2, Jameen Arm^1,2, Neda Gholizadeh¹, Rodney Lea³, Jeannette Lechner-Scott^3,4,5, and Saadallah Ramadan^1,2

¹School of Health Sciences, University of Newcastle, Newcastle, Australia, ²Imaging center, Hunter Medical Research Institute, Newcastle, Australia, ³Hunter Medical Research Institute, Newcastle, Australia, ⁴School of Medicine and Public Health, University of Newcastle, Newcastle, Australia, ⁵Department of Neurology, John Hunter Hospital, Newcastle, Australia

This study aims to evaluate and compare DTI parameters in relapsing-remitting MS patients with age and sex-matched healthy controls, and to correlate these DTI metrics with clinical symptoms and brain volumetric measures. As a result, There was a statistically significant increase in most of DTI parameters for RRMS patients compared with healthy controls. FA correlated positively with clinical parameters like EDSS and cognitive assessment. Both MD and RD correlated negatively with cognition parameters and positively with EDSS. Quantitative DTI parameters not only differentiate between RRMS patients and HCs, but are also associated with disability and mental health of RRMS.

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