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Abstract #4705

3D High Resolution T1 and T2 Mapping at Ultrahigh Fields Using Magnetic Resonance Fingerprinting

Yuning Gu1, Yun Wu2, Hongyi Yang2, Yong Chen3, Jesse I. Hamilton4, Nicole Seiberlich3,4, Charlie Androjna5, Kai Zhong2, and Xin Yu1,3,6
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, China, 3Department of Radiology, Case Western Reserve University, Cleveland, OH, United States, 4Department of Radiology, University of Michigan, Ann Arbor, MI, United States, 5Cleveland Clinic Pre-Clinical Magnetic Resonance Imaging Center, Cleveland Clinic Foundation, Cleveland, OH, United States, 6Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States

This study demonstrates the development of a 3D T2-prepared MRF sequence, in combination with a stack-of-spirals trajectory, for simultaneous T1 and T2 mapping of an ex vivo macaque monkey (Macaca mulatta) brain with a voxel size of 0.35x0.35x1 mm3. Retrospective evaluation of the undersampling accuracy showed that, for an undersampling rate of up to 16, the normalized root mean square error was within 6% and 15% in T1 and T2 mapping, respectively. These results suggest that 3D simultaneous T1 and T2 mapping can be in <30 min with unprecedented spatial resolution.

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