Two rabbit model types (Watanabe Heritable Hyperlipidemic and Apolipoprotien E knockout) were studied with vessel wall MRI (vwMRI) and confirmatory histopathological analysis to evaluate for presence of intracranial atherosclerosis (ICAD). Disease was reliably produced in both rabbit types. Sensitivity and specificity of vwMRI for detection of ICAD were 89.5% and 91.9%, respectively. When excluding mild cases to assess accuracy vwMRI for detecting moderate to severe ICAD lesions, sensitivity improved to 100% with unchanged specificity.
This abstract and the presentation materials are available to members only; a login is required.