Both interstitial fluid pressure and solid pressure of tumours have been shown to correlate with decreased efficacy of treatment and potentially with poorer prognosis. This increased fluid and solid pressure causes tumours to push on surrounding tissue, leading to changes in tissue stiffness due to nonlinear effects. A previously presented method relates the magnitude of these changes, as measured by MR elastography, to pressure using a nonlinear biomechanical model. Here, this method is extended for use on both preliminary liver and brain data which show correlation between reconstructed pressure and invasion and tumour type, respectively.
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