Our study aims to develop and evaluate an examination using Synthesis MRI based T1, T2, and proton density (PD) mapping for multiparametric characterization of prostate cancer. T1, T2 and PD mapping exhibited excellent differential diagnosis of normal prostate, prostatitis and Prostate cancer (PCa) and discrimination performance was better than ADC. T1, T2 and PD mapping of synthetic quantitative MRI seem to be a potential method in PCa detection. It may aid prostate biopsy by means of guiding and controlling localized therapy delivery. This preliminary study showed that synthetic MRI has a potential in the detection and characterization of PCa.