Abstract #4853

Prospective assessment of DCE-MRI parameters associated with advanced mandibular osteoradionecrosis after IMRT of head and neck cancer

Abdallah Sherif Radwan Mohamed¹, Renjie He¹, Yao Ding¹, Jihong Wang¹, Joly Fahim¹, Baher Elgohari¹, Hesham Elhalawani¹, Jason Johnson², Jason Stafford³, Jim Bankson³, Mark Chambers⁴, Vlad Sandulache⁵, Clifton Fuller¹, and Stephen Lai⁴

¹Radiation Oncology, MD Anderson Cancer Center, Houston, TX, United States, ²Diagnostic imaging, MD Anderson Cancer Center, Houston, TX, United States, ³Imaging physics, MD Anderson Cancer Center, Houston, TX, United States, ⁴Head and Neck Surgery, MD Anderson Cancer Center, Houston, TX, United States, ⁵Baylor College of Medicine, Houston, TX, United States

Our aim was to characterize the quantitative DCE-MRI parameters associated with advanced mandibular osteoradionecrosis (ORN) in comparison with normal mandible. Thirty patients with advanced ORN after radiation of head and neck cancer were prospectively enrolled. Our results confirm there is a quantitatively significant higher degree of leakiness in the mandibular vasculature as measured using DCE-MRI parameters of areas affected with advanced grade of ORN versus healthy mandible. We were able to measure significant increases in quantitative parameters (3.3 fold K^trans, 3 fold v_e) compared to non-ORN mandibular bone.

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