Head and neck cancers have a high propensity to metastasize to the lymph nodes of the neck. Accurate knowledge of this regional nodal status is of great importance for therapy selection and prognosis. Ultrasmall superparamagnetic iron oxide (USPIO) particles (Ferumoxtran-10 / Ferrotran®) are a promising contrast agent that can be used to detect nodal metastases with MRI. This study aims to validate USPIO-MRI for the detection of nodal metastases in head and neck cancer patients with histopathology as the reference standard. The workflow and preliminary results in 5 patients are shown in this abstract.