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Abstract #0041

Compound 48/80 induced mast cell activation in the lung

Mazzoni L, Cannet C, Zurbruegg S, Quintana H, Bl F, Fozard J, Page C, Beckmann N
Novartis Institutes for BioMedical Research

The effects of mast cell activation by compound 48/80 were investigated non-invasively in the lungs of nave Brown Norway (BN) rats by proton magnetic resonance imaging (MRI). A peak edematous response was observed 24 h after 48/80 and was fully inhibited immediately following pre-treatment with a mast cell stabilizer (di-sodium cromoglycate, DSCG) and the steroid budesonide administered 1 h before or 3 h after 48/80. Histamine and 5-HT antagonists did not block the late phase (24h) edema induced by 48/80.