ADC measurement in the middle cerebellar peduncle allows the differentiation of MSA from PD and PSP
Quattrone A, Pugliese P, Arabia G, Zappia M, Barbiroli B, Tonon C, Nicoletti G, Fera F, Malucelli E, Manners D, Condino F, Lodi R
Institute of Neurological Sciences
Clinical differentiation of Parkinsons disease (PD) from parkinsonian syndromes such as multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) is difficult in the early stage of the disease, with a high rate of misdiagnosis. We used DWI to extensively assess ADC values in the middle cerebellar peduncles (MCP), brainstem, basal ganglia and cerebral white matter regions in patients with PD, MSA, and PSP. ADC in the MCP differentiated MSA patients both from PSP, PD patients and healthy volunteers with 100% sensitivity and 100% specificity. ADC measurement of MCP should be included in the clinical work-up of parkinsonian syndromes.