Assessment of White Matter Damage in Subacute Sclerosing Panencephalitis using Quantitative Diffusion Tensor MRI
Trivedi R, Gupta R, Agarwal A, Hasan K, Gupta A, Prasad K, Narayana P
Sanjay Gandhi Post Graduate Institute of Medical Sciences
Diffusion tensor imaging data were acquired from twelve patients of stage II subacute sclerosing panencephalitis (SSPE) and ten age and sex-matched healthy controls. Fractional anisotropy (FA) and mean diffusivity (MD) values were calculated in the periventricular white matter, corpus callosum and posterior limb of the internal capsule in patients as well as healthy controls. Statistically significant decreased FA in white matter and increased MD in the parieto-occipital region were found in patients with normal as well as abnormal conventional imaging compared to healthy controls. We conclude that FA and MD changes are widespread in the white matter in SSPE that may help in the early diagnosis and management of these patients.