Spectroscopic monitoring of an experimental brain lesion treated by cell transplantation
Herynek V, Glogarov K, Jendelov P, Sykov E, Hjek M
Institute for Clinical and Experimental Medicine, 2nd Faculty of Medicine, Charles University
An experimental cortical lesion in the rat brain was monitored after treatment by cell transplantation. Higher concentrations of NAA and glutamate and lower concentrations of glutamine, as assessed by 1H MRS, in treated animals compared to untreated ones indicated faster recovery of the affected tissue after cell therapy. Although complete recovery or replacement of damaged neurons cannot be expected within a short time period, transplanted cells might rescue partially damaged cells, resulting in a decrease in the penumbra area and enabling faster regeneration of the tissue.