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Abstract #0161

Differences between Boys and Girls in the Correlation of Functional Brain Connectivity and Intelligence

Schmithorst V, Holland S
Children's Hospital Medical Center

The neuroanatomical correlates of intelligence and their developmental trajectories in boys and girls were investigated using functional MRI (fMRI). A large cohort of over three hundred children performed the task of silent verb generation. Regions were found in the left hemisphere exhibiting positive correlations of functional activation with IQ, including the medial temporal gyrus, prefrontal cortex (Brocas area), medial frontal gyrus, precuneus, and cingulate gyrus. Using a data-driven analysis procedure, a sex-X-IQ-X-age interaction was demonstrated in the functional connectivity between regions in the left hemisphere. Our results provide evidence for disparate neuroanatomical bases underlying intelligence in boys and girls.