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Abstract #0273

Focal Wallerian Degeneration of Corpus Callosum in Large Middle Cerebral Artery Stroke: Serial Diffusion Tensor Imaging

Saksena S, Gupta R, Hasan K, Agarwal A, Haris M, Pandey C, Narayana P
Sanjay Gandhi Post-Graduate Institute of Medical Sciences

Diffusion tensor imaging data were acquired from eight patients with symptoms of large middle cerebral arterial territory stroke and eight healthy age matched controls at different time points. Region-of-interest analysis was performed on seven segments of the corpus callosum for determining the fractional anisotropy (FA), mean diffusivity, and the corresponding callosal cross-sectional areas. A significant temporal decline in FA values was observed suggesting cortico-callosal wallerian degeneration in these patients.