Screening women at genetic risk of breast cancer using DCE-MRI: the effect of gene mutation status on detection sensitivity, specificity and cancer characteristics
Leach M, Maribs Study Group T
Institute of Cancer Research
MRI is a sensitive method of detecting cancer in younger women at genetic risk of breast cancer. Combination of MRI with XRM provides a test with a sensitivity of 86%-94%, compared with about 40% for XRM alone. Decisions on how to provide screening for such high risk groups depends on a knowledge of sensitivity in particular risk groups. In this study we present sensitivity and specificity for MRI and XRM alone and in combination in women with BRCA1 or BRCA2 breast cancer predisposition mutations, or women at high familial risk who tested negative for both of these mutations.