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Abstract #0464

Vascular Tortuosity is Culprit to Abnormal Perfusion in 9L Gliosarcoma Tumor

Schmainda K, Wu F, Molthen R, Darpolor M
Medical College of Wisconsin

Cerebral perfusion in brain tumor is quite inefficient as demonstrated by dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI). This inefficient perfusion is attributed to the density of irregularly shaped vessels in rat brain tumors as elucidate by micro-computed tomography of intact vessel tree. It is shown that the density of tortuous vessels is the prime suspect of abnormal perfusion. Validation of DSC-MRI parameters could ensure its use to assess vessel attributes in brain tumors.