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Abstract #0475

Anti-adipogenic Effects of a Diet High in Resistant Starch

So P, Yu W, Bell J, Frost G
Hammersmith Hospital, Imperial College London

Approaches to ameliorating obesity include ingestion of low glycaemic index (GI) foods. High GI foods induce high blood glucose levels leading to hyperinsulinaemia, linked to the metabolic syndrome. In this study, the effect of diets high in resistant starch (and of low GI) on adiposity and intrahepatocellular lipid (IHCL) levels was investigated by 1H MRS in a murine model. Maintenance on a diet high in resistant starch leads to similar weight gain to that on a low resistant starch diet but the former diet led to both comparatively lower adipose tissue deposition and accumulation of IHCL levels than the latter.