Abstract #0476

Solanky B, Leverton E, Snaar J, Morris P, Taylor R, Jovanovich A

13C spectroscopy was used to investigate the second meal effect. The rise in blood glucose after breakfast is much greater than the rise after a lunch. This is possibly due to suppressed hepatic glycogen output after lunch. Our study was designed to investigate this by observing the differences in glycogen levels for subjects given breakfast plus lunch and lunch only in the liver and thigh.We found that the increase in hepatic glycogen levels after lunch were 61% higher in subjects that had breakfast. A similar trend was observed in the thigh glycogen concentrations with the increment being 50% higher.