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Abstract #0482

13C MRS of muscle and hepatic glycogen metabolism in type I diabetes to investigate muscle exhaustion

Leverton E, Snaar J, Solanky B, Macdonald I, Morris P, Chokkalingam k, Norton L
University of Nottingham

By using 13C MRS, the postprandial hepatic and muscle glycogen storage after intense exercise in subjects with type I diabetes was compared to normal healthy subjects. It was expected that the exhaustion suffered by type I diabetics during exercise may be due to low glycogen stores. The study found hepatic glycogen homeostasis behaves similarly to controls when blood insulin levels are controlled. Thigh muscle glycogen storage differed from controls, with the levels remaining higher after exercise. This suggests that a failure for the muscle to utilise glycogen may be the reason behind exhaustion in type I diabetics.