Abstract #0481

Machann J, Thamer C, Schndt B, Stefan N, Hring H, Claussen C, Fritsche A, Schick F

Quantification of changes in adipose tissue after lifestyle intervention in a group of 130 volunteers at increased risk for type 2 diabetes. MR examinations before and after participation in a dietary intervention and increased activity (at least 4 h sports/week). Separation of different lipid compartments by MRI, additionally determination of intrahepatic lipids (IHL) by MRS. Volunteers with weight loss (n=90) are characterized by massive reduction of visceral adipose tissue (VAT) and IHL. In volunteers with increased body weight, these compartments were nearly unchanged. VAT and IHL seem to be very important lipid compartments and are metabolically highly active.