Quantitative Micro-MRI Demonstrates Significant Effects on Trabecular Bone Architecture in Response to Antiresorptive Therapy
Vasilic B, Wehrli F, Ladinsky G, Saha P, Wright A, Song H, Zemel B, Snyder P, Peachy H
University of Pennsylvania
Advances in MR image acquisition and processing techniques now have made possible direct imaging of trabecular microarchitecture and assessment of the topological changes that occur during the pathogenesis and treatment of patients with osteoporosis. Comparing a group of women ages 45-55 years in early menopause treated with estrogen against a control group without hormonal therapy, we provide evidence for the postulated architectural changes in response to antiresorptive treatment and show that these effects can be visualized in vivo in individual patients.