Development and Evolution of Glioma after ENU exposure: A Model of Malignant Transformation of Low Grade Gliomas
Sathy B, Hsu Y, Recht L, Jang T, Chang C
Functional and Micro-MRI Center, Institute of Biomedical Sciences, Academia Sinica
MRI was used to detect the evolution of chemically induced experimental brain tumors in rats after in utero exposure to ethyl-nitrosourea (ENU). Both T2WI and DWI were used to acquire brain images every 15 days from postnatal day 30 to day 210. T2WI images of early and advanced gliomas were correlated with histology. Tumor growth rate and CNR were serially assessed during tumor development.