In Vivo DTI-Based Tractography of Intra-Cranial Rat Brain Tumors
Kim S, Pickup S, Hsu O, Poptani H
University of Pennsylvania
There have been only a limited number of in vivo and ex vivo reports on tractography of the rat brain without providing a systematic approach to reconstruct individual white matter fiber bundles. The availability of DTI-based tractography of rat brain in vivo might be useful for studying changes in the white matter tracts due to a pathology. These studies could then be validated with invasive measurements that are not feasible in the clinic. We developed a DTI data acquisition and tractography method for in vivo rat brain and demonstrated its application in monitoring the growth of intra-cranial rat tumor.