Abstract #0646

Alexander A, Wu Y

Many approaches have been proposed to study the complex diffusion behavior in brain tissues with crossing white matter (WM) fibers. Hybrid diffusion imaging (HYDI) combines the advantages of diffusion spectrum imaging (DSI) and high angular resolution diffusion imaging for complex diffusion characterization. In this study, Monte Carlo noise simulations were used to compare the measurements accuracy of DSI and HYDI for estimating the properties of the diffusion displacement spectra in complex WM. HYDI and DSI performed similarly for estimating scalar measures of the diffusion spectrum, whereas the outer HYDI shell was generally superior for resolving and characterizing crossing WM orientations.