High Resolution In Vivo Magnetic Resonance Imaging and Image Quantitation of the Progression of the Murine Aortic Atherosclerotic Plaque
Tang H, Liu H, Miller C, Rosa R, Williams D, Rex_Rabe S, Peterson L, Hargreaves R
Merck Research Laboratories
MRI is becoming an important imaging modality for detecting and characterizing atherosclerosis because of its non-invasive and high-resolution capability. Atherosclerotic plaque detection requires imaging protocols with high spatial resolution and high contrast-to-noise ratio. Our purpose was to establish a high resolution in vivo MRI technique for the evaluation and quantitation of the progression of atherosclerosis in a transgenic mouse model based on Ldlr null. High resolution 3D MR imaging and quantitation of aortic atherosclerotic plaque were demonstrated.