Abstract #0675

Wirestam R, Knutsson L, Sthlberg F, Larsson E, Brjesson S, Risberg J, Passant U, Gustafsson L

Reproducible absolute quantification of cerebral blood flow (CBF) is desirable, for example, in therapy monitoring, in the assessment of ischemic threshold levels in acute ischemic stroke and when a global reduction of CBF can be expected as, for example, in patients with dementia. In this study, a comparison between CBF estimates from dynamic susceptibility contrast (DSC) MRI and Xe-133-SPECT was performed in 20 healthy volunteers. The correlation between CBF estimates obtained by DSC-MRI and Xe-133-SPECT was quite reasonable (r=0.76) and if proportionality between the DSC-MRI-based and SPECT-based CBF results is assumed, i.e. CBF(MRI)=k&[middot]CBF(SPECT), the present data indicates that k=2.16.