The Minimum Detectable Change in Water Diffusion Across DTI Sessions
Goodyear B, Lau R
University of Calgary
As myelin is destroyed during the progression of Multiple Sclerosis, the local fractional anisotropy (FA) of water diffusion as measured by diffusion tensor imaging (DTI) decreases. To track disease progression and assess treatment, there is a need to measure FA during the progression of MS in individual patients. In this study, we determine the minimum detectable change in FA, mean diffusion (MD), and transverse diffusion (TD) across imaging sessions. As a result, this will determine if the precision of FA, MD, and TD is sufficient for clinical use to monitor the progression of white matter disease.