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Abstract #0797

Negative BOLD Signals Correlate with Synchronized Delta Oscillations Induced by Heroin in the Nucleus Accumbens of the Rat Brain

Hudetz A, Schulte M, Li S, Luo F
Medical College of Wisconsin

It is not clear how negative BOLD signals are linked to changes in field potentials. In the present study, a rat model was employed and the measurements of local EEG changes in the nucleus accumbens were performed before, during and after systemic administration of heroin. Under the same experimental conditions, a negative BOLD signal in the nucleus accumbens was robustly measured. The analysis of EEG oscillations revealed that heroin shifted the mean power frequency from 8Hz to 3Hz and that this frequency shift was correlated with the negative BOLD signal that could be resulted from the GABAergic inhibitory activity.