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Abstract #0798

BOLD response to the agonist THC and to the selective antagonist, Rimonabant: an fMRI study in the rat brain

Luckman S, Williams S, Stark J
University of Manchester

Delta-9-tetrahydrocannabinol (THC), an agonist at cannabinoid 1 receptors in the brain, increases food intake in sated animals. We are investigating appetite regulation by cannabinoids in rats using high field BOLD fMRI. Animals were administered either THC or the cannabinoid receptor 1 antagonist rimonabant, and their brains scanned. Drug groups were analysed separately using SPM2 due to drug vehicles being different. Results show that rimonabant had consistent opposite effects in areas modulated by THC.