Quantitative cerebral blood volume measurement using the Bookend Method : water exchange effect correction and diagnosis on tumor in gradient-echo and spin-echo EPI
Shin W, Cashen T, Carroll T, Horowitz S
However qunatitative cerebral blood volume (qCBV) measurement can diagnose the abnormalties of the brain, accurate qCBV measurement with a whole brain coverage has remained challenaging in clinical use. Quantification of relative CBV maps from dinamic susceptibility contrast analysis was performed by the Bookend method with correction of water exchange effects. Based on qCBV maps, pre-confirmed tumor was diagnosed and compared with normal tissue in gradient-echo and spin-echo EPI.