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Abstract #0896

Understanding the Intra- and Extravascular contributions to the BOLD effect through simulations

Marques J, Bowtell R
Universidade de Coimbra

By using a 3D finite element method to simulate BOLD signal changes produced by infinite cylinders and a more realistic model of the human cortical vasculature and comparing the results obtained, this abstract assesses the reliability of the infinite cylinder model used previously in the literature. A simple parametrisation of R2* changes as a function of blood volume and susceptibility has also been carried out, allowing a discussion of the variable form of the haemodynamic response at different fields. Using the realistic model it is also possible to explore the coupling between intra and extravascular contrast.