Cerebral Metabolic Abnormalities and Correlations with Cognition in Children with Pervasive Developmental Disorder: A Preliminary Proton MRS Study
Huang W, Tudorica L, Pomeroy J, Gabis L, Azizian A, DeVincent C, Roche P, Bilski J, Sclafani S
Memorial Sloan-Kettering Cancer Center
Single-voxel proton MR spectra were acquired from left and right hippocampus-amygdala (LHA and RHA) regions and cerebellum of children with Pervasive Developmental Disorder (PDD) and healthy controls. In all or some of the brain regions examined, NAA/Cr was significantly decreased, while Cho/Cr and mI/Cr were significantly increased in the PDD group. LHA Cho/Cr was inversely associated with visual discrimination ability, while RHA NAA/Cr and mI/Cr were positively related to performance IQ. Combined approach of proton MRS and neuropsychological measurements may provide insight in understanding the underlying neuropathology of PDD.