Comparison of MRI with Histopathology in T-cell Clone Mediated Mouse EAE
Watanabe T, Michaelis T, Stadelmann C, Frahm J, Boretius S, Nessler S
Max-Planck-Institut fuer biophysikalische Chemie
In a clonal EAE mouse model two dominant lesion patterns with distinct histopathological findings were identified. Type A lesions were characterized by a reduction of signal intensity on both T1- and T2-weighted images, whereas type B lesions appeared as hyperintensities on T2- and slightly reduced or isointense signals on T1-weighted images. Histopathologically, type A lesions showed a significantly higher inflammatory cell density and more myelin loss than type B. Thus, high resolution 3D MRI not only proved useful for the assessment of lesion pathology, but also offers a promising tool to monitor lesion development and novel therapeutic strategies.