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Abstract #0942

High-resolution MRI of NPC mice shows neurological changes prior to onset of disease symptoms

Erickson R, Allee-Jumbo E, Lin L, Hicks C, Chaitkin E, Lope-Piedrafita S, Chen K, Trouard T, Alexander G
University of Arizona

High-resolution (100um isotropic) 3D MRI was used to longitudinally track brain volume changes in NPC mice versus controls. NPC mice were found to exhibit retarded growth and eventual atrophy compared to controls. Also, NPC mice showed hyperintensity in white-matter tract indicating a lack of myelin.