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Abstract #0944

Intranasal insulin delivery is protective against diabetes mellitus-related brain atrophy and white matter abnormalities in experimental diabetes mellitus

Toth C, Tuor U, Zochodne D
University of Calgary

Diabetes mellitus (DM) is associated with cognitive decline, brain atrophy, white matter changes, and even dementia. We studied experimental DM in mice receiving intranasal delivery of insulin or placebo. Compared to control mice, DM mice showed cognitive decline after 6-7 months which was prevented by intranasal insulin, which also prevented brain atrophy. Intranasal insulin prevents brain atrophy in experimental DM.