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Abstract #0998

Real time monitoring of hyperosmolar blood brain barrier disruption using MRI

Fortin D, Lepage M, Pellerin M, Tremblay L, Blanchette M
Universit de Sherbrooke

Different approaches have been advocated to improve delivery across the blood brain barrier (BBB). One such strategy is the osmotic opening of the BBB. This study was initiated with the goal of characterizing spatially and temporally the BBBD procedure with MRI. We report on the amplitude, rate of accumulation and localization of a contrast agent injected shortly after BBBD.