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Abstract #0999

Implementation and evaluation of an MRI protocol for assessment of cerebrovascular reserve in the rhesus monkey characterizing the aging brain

Holahan M, Coimbra A, Cook J, Hargreaves R, Tymofyeyev Y, Williams D
Merck Research Laboratories

Cerebrovascular autoregulation ensures adequate blood perfusion to match demands for oxygen and nutrients. Cerebrovascular reserve (CVR) is defined as the maximal capacity under a vasodilatory challenge. The present work used MRI to measure CVR in rhesus brains, in order to evaluate its responsiveness and test-retest repeatability in readiness for possible use in clinical trials.