Developing an arterial spin labeling technique for measuring cerebral blood flow in pediatrics: Comparison with Computed Tomography Perfusion
Koziak A, Winter J, St. Lawrence K, Thompson R, Lee T
Lawson Health Research Institute, University of Western Ontario
As part of a longterm strategy of developing an arterial spin labeling (ASL) technique for imaging cerebral blood flow (CBF) in neonates, the purpose of this study was to validate the ASL CBF measurements by comparison with perfusion computed tomography (pCT). Images of CBF were collected with ASL and pCT in a neonatal animal model (piglets). The two techniques showed similar flow patterns and there was reasonable agreement in the global CBF measurements. However, vascular artifacts were evident with both techniques, which needs to be addressed in future work.