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Abstract #1005

Limits on quantification of perfusion and capillary permeability surface area product using FAIR ASL

Buckley D, Carr J, Tessier J, Parker G
University of Manchester

In this study we look specifically at the use of ASL in normal brain of rats and humans to measure F and PS. We investigate the experimental limits on F and PS quantification using simulations and experimental verification in rat brain at 9.4 T. We ascertain the expected error on FAIR-based F and PS measurements and quantify the % changes in these parameters that can be resolved experimentally. Our results allow us to judge the feasibility of PS measurements the precision of F using FAIR ASL.