Abstract #1154

Qiu M, Constable R, Ramani R

Quantitative measures of the change in CMRO2, can be obtained through models relating regional cerebral blood flow (rCBF) and blood oxygen level dependent (BOLD) contrast. This abstract presents results from a study showing the complicated effects of an anesthetic agent on basal neuronal activity. Most important for fMRI studies, the spatial-specificity of the drug-induced incremental changes in rCBF and the confounding vascular effect of the agent, are investigated.