Meeting Banner
Abstract #1154

Spatial Non-Uniformity of the CBF Response to Sevoflurane: Implications for fMRI

Qiu M, Constable R, Ramani R
Yale University School of Medicine

Quantitative measures of the change in CMRO2, can be obtained through models relating regional cerebral blood flow (rCBF) and blood oxygen level dependent (BOLD) contrast. This abstract presents results from a study showing the complicated effects of an anesthetic agent on basal neuronal activity. Most important for fMRI studies, the spatial-specificity of the drug-induced incremental changes in rCBF and the confounding vascular effect of the agent, are investigated.