Positive Enhancement of Microvascular Obstruction in Reperfused Acute Myocardial Infarction Using T1 Prep Look-Locker Sequence: a Short Time-course Study
Foltz W, Yang Y, Graham J, Detsky J, Dick A, Wright G
Sunnybrook and Women's College Health Sciences Centre, St.Michael Hospital
DE-MRI has been used for the determination of myocardial viability and can delineate the extent of myocardial infarction as a positive contrast. However, negative contrast can result from microvascular obstruction (MO) that is a strong unfavorable predictor for clinical outcome in these patients. A noninvasive MRI technique with positive enhancement of MO will improve the identification of MO, and thus would have value in MRI evaluation in patients with AMI. This study investigates a T1 prep acquisition during a Gd-DTPA infusion for the positive enhancement of MO in a porcine model of reperfused AMI and demonstrates its early time course.